Effects of rehabilitation training on the expression of Fos in the central nervous system of rats with cerebral infarction
- VernacularTitle:康复训练对脑梗死大鼠中枢神经系统Fos表达的影响
- Author:
Ling LI
;
Hua YUAN
;
Li XU
- Publication Type:Journal Article
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2001;23(1):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of rehabilitation training on the expression of Fos in the central nervous system(CNS) of rats with cerebral infarction. Methods 60 SD rats were made as cerebral infarction models and divided into 2 groups at random 24 hours later: rehabilitation group was given balancing, grasping, rotating and walking and other trainings everyday, while immobiligation group was fixed in cages. Immunohistochemistry was used to detect the Fos expression 1 d, 7 d, 14 d, 21 d and 28 d after infarction respectively. Results Fos-positive immune reaction appeared in cortex,thalamus, hypothalamus, reticular form and posterior gray horn of the spinal cord of both groups .Rehabilitation group responded stronger than the immobilization group significantly (P<0.01).Conclusion Rehabilitation training can activate cortical neurons around the infarted focus and in its opposite side of the CNS, and thus promote the recovery of rats' motor functions.
