Development of the scavenger receptor B type Ⅰ research
10.3760/cma.j.issn.1673-4203.2011.01.011
- VernacularTitle:B类Ⅰ型清道夫受体的研究进展
- Author:
Huaming TANG
;
Zhengming LEI
- Publication Type:Journal Article
- Keywords:
Scavenger receptor B type Ⅰ;
Cholesterol;
Lipid
- From:
International Journal of Surgery
2011;38(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Scavenger receptor B type Ⅰ (SR-BI) is a HDL receptor which fivst identified at molecular level. It can mediate the metabolism of cholesterol and other lipids between HDL and cells, involving in intestinal absorption of cholesterol, and mediate outflow of cholesterol from peripheral tissues to promote the selective uptake of cholesterol by the liver and transfer in liver cells, and then secrete cholesterol into the bile through the bile duct side of the membrane. This process can affect cholesterol levels in bile. In this review,we discuss the process of SR-BI-mediated cholesterol metabolism.
