Effect of Carbamazepine on the Ouabain-Induced Arrhythmia in Rabbits.
10.12701/yujm.1986.3.1.279
- Author:
Eui Hong KIM
;
Jeoung Hee HA
;
Kwang Youn LEE
;
Won Joon KIM
- Publication Type:Original Article
- MeSH:
Anticonvulsants;
Antidepressive Agents, Tricyclic;
Arrhythmias, Cardiac*;
Atrial Fibrillation;
Blood Pressure;
Bradycardia;
Carbamazepine*;
Catheters;
Digitalis;
Electrocardiography;
Electrodes;
Femoral Artery;
Femoral Vein;
Heart Block;
Leg;
Ouabain;
Phenytoin;
Polyethylene;
Rabbits*;
Tachycardia;
Tachycardia, Ventricular;
Trachea;
Trigeminal Neuralgia;
Urethane;
Ventilators, Mechanical
- From:Yeungnam University Journal of Medicine
1986;3(1):279-285
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Carbamazepine is a derivative of iminostilbene with carbamoyl group and related chemically to the tricyclic antidepressants. Carbamazepine has been introduced for treatment of trigeminal neuralgia. Recently it is used as an antiepileptic agent such as diphenylhydantoin. Antiepileptic drugs are known to affect experimentally induced cardiac arrhythmia and are now widely used clinically for treatment of ventricular tachyarrhythmias, particularly those produced by digitalis intoxication. Steiner et al. (1970) reported that carbamazepine was found to be very effective in converting ventricular tachycardia due to digitalis toxicity to normal sinus rhythm. Clinically bradycardia, complete heart block, ventricular standstill and Adams-stokes attack were reported in the course of carbamazepine treatment. The purpose of this study was to investigate the effects of carbamazepine on the ouabain-induced arrhythmia in vivo. The rabbits of either sex, weighing from 1.6 to 3.2 kg were anesthetized by urethane. After the trachea was cannulated, the rabbits were ventilated with room air using a respirator. Drugs were given into polyethylene cannula in the femoral vein. Blood pressure were recorded by physiograph via pressure tranducer connected with the cannula in the femoral artery. EKG were recorded by physiograph via electrode implanted in both fore leg and left hind leg. The results are summarized as follows 1. Arrhythmia was induced by continuous infusion of ouabain (65±8.8 µg/kg). 2. Single administration of ouabain (64 µg/kg) induced arrhythmia which was persisted for 7-8 min. 3. Ouabain induced arrhythmia was restored to normal sinus rhythm by administration of carbamazepine (the more dosage, the less frequent and the longer duration). 4. Severe bradycardia, A-V block, atrial fibrillation were seen on the EKG after injection of carbamzepine alone. By the above results, it may be concluded that carbamzepine inhibits the ouabain-induced arrhythmia by dose-dependent.
