Dynamic determination of serum osteopontin level in Pre-and postoperative patients with non-small cell lung cancer
- VernacularTitle:动态检测非小细胞肺癌患者手术前后血清骨桥蛋白水平的临床意义
- Author:
Wenbin ZHOU
;
Ming BAI
;
Yang JIN
;
Yuan WU
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Pulmonary neoplasm;
Osteopontin
- From:
Cancer Research and Clinic
2008;20(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of serum osteopontin levels in preoperative and postoperative patients with non-small cell lung cancer (NSCLC) and its clinic significance.Methods The levels of serum osteopontin were detected by ELISA.Results In 88 NSCLC patients,serum osteopontin levels were significantly higher than in benign pulmonary disease and healthy control group(P＜0.05.P＜0.01.respectively) There was no difference between benign pulmonary disease and healthy control group(P＞0.05).Serum osteopontin levels were related to clinical stage and lymph node metastasis,and the levels of serum osteopontin were lower in postoperative patients than in preoperative cases(P＜0.05).For NSCLC.the detection of osteopontin had a sensitivity of 84.1%,a specificity of 92.5%,and an accuracy of 88.1%. Conclusion Increased serum levels of osteopontin may be useful as a helpful clinical biomarker to diagnose earlier,predict prognosis and differentiate from benign pulmonary disease.
