Study on IgA Fc receptor-mediated neutrophil degranulation
- VernacularTitle:IgA Fc受体介导的中性粒细胞脱颗粒反应的机理研究
- Author:
Bo BI
;
Wei ZHANG
;
Minlu SHI
- Publication Type:Journal Article
- From:
Chinese Journal of Microbiology and Immunology
2001;21(2):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pattern of human neutrophil degranulation mediated by Fc alpha receptors. Methods IgA immune complexes (IgA IC) and specific monoclonal antibody were used to stimulate neutrophil degranulation. Lactoferrin released by stimulated neutrophils was quantitatively determined. Results Monoclonal antibody and IgA IC could both induce neutrophil lactoferrin release. However, monoclonal antibody induced rapid and strong degranulation whilst the effect of IgA IC was much weaker. Conclusion The pattern of neutrophil degranulation induced by IgA IC and monoclonal antibody is different.
