Expression of Bcl-2 and Bax in different phases of human dermal hemagniomas
- VernacularTitle:Bcl-2和Bax在皮肤血管瘤组织中的表达及意义
- Author:
Shengguo SHAN
;
Duanlian ZHANG
;
Yu LIU
;
Ying YU
;
Yong YANG
;
Yane XIONG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Bcl-2;
Bax;
Hemangioma;
Apoptosis;
Immunohistochemistry
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2008;14(2):118-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of Bcl-2 and Bax in the pathogenesis,development and regression of human hemangiomas.Methods We examined the expression of Bcl-2 and Bax in proliferating versus involuting human hemangioma tissues and normal skin tissues using immunohistochemical technique.Results The expression of Bcl-2 in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues(P＜0.01).No significant difference was found between the expression of Bcl-2 in involuting hemangiomas and that in normal skin tissues(P＞0.05).The expression of Bax in involuting hemangiomas was significantly higher than that in proliferating hemangiomas and normal skin tissues(P＜0.01);the expression of Bax in proliferating hemangiomas was significantly higher than that in normal skin tissues(P＜0.05).Conclusion Bcl-2 and Bax participate in the development and involution of hemangioma,Bcl-2 plays a role in accelerating the proliferation of hemangioma by inhibiting the apoptosis of endothelial cells,and Bax promotes the switching from proliferation to involution in hemangiomas through inducing the apoptosis of endothelial cells.
