Expression of NF-κB,COX-2 and the MMP-9 in hypopharyngeal carcinoma
- VernacularTitle:细胞核因子-κBp65、环氧合酶-2和基质金属蛋白酶-9在下咽癌中表达的临床意义
- Author:
Yanzhao WU
;
Chen XIONG
;
Huijing SHI
;
Shijie WANG
- Publication Type:Journal Article
- Keywords:
Hypopharyngeal neoplasms;
Transcription factor RelA;
Prostaglandin-endoperoxide synthase;
Matrix metalloproteinase 9
- From:
Cancer Research and Clinic
2008;20(3):172-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the quantitative expression and the correlation of the NF-κB p65,COX-2 and MMP-9 Drotein in the hypopharyngeal carcinoma tissue.Methods FCM method was performed to detect the quantitative expression of the NF-κB p65,COX-2 and MMP-9 protein in 48 cases of hypopharyngeal carcinoma fresh sample and 48 cases of para-carcinoma tissue.Fluorescence Index wasdeftned as the quantitative expression index of the three proteins.Results The quantitative expression of the NF-κB p65,COX-2 and MMP-9 in hypopharyngeal carcinoma tissues(1.16,1.32 and 1.26) was remarkably higher than in para-carcinoma(1.03,1.04 and 1.04).The quantitative expression of three proteins in metastasis group was obviously higher than in non-metastasis group.The expression of NF-κB p65 and COX-2 protein in hypopharvngeal carcinoma tissues was positively related (P＜0.05). Conclusion The high expression of NF-κB p65 and COX-2 is closely related in hypopharyngeal carcinoma tissues.NF-κB p65 might improve the expression of COX-2.
