Research advances in relationship between methyl-CpG binding domain proteins and the repression of tumor repressor genes
- VernacularTitle:甲基化结合蛋白与抑癌基因失活
- Author:
Lingling GUO
;
Fengying DUAN
;
Xiaohua QIU
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Genetic;
Genes,tumor suppressor
- From:
Cancer Research and Clinic
2008;20(3):211-213
- CountryChina
- Language:Chinese
-
Abstract:
Many genetic events have been described to be involved in the development of tumor,but a lot of recent researches proved that epigenic events also played an important role in it.DNA methylation is one of the common modification of epigenic events,the binding of methyl-CpG binding domain proteins has been shown to lead to transcriptional repression of many tumor repressor genes.
