Study on the immunogenicity of group A plus group C meningococcal glycoconjugate vaccine
- VernacularTitle:A、C群脑膜炎球菌结合疫苗免疫原性研究
- Author:
Jianhua WANG
;
Meiying LIU
;
Yeshan LI
;
Jingrong GUO
;
Yanbin ZHANG
;
Yun CHEN
;
Hua GAO
;
Yun LIN
;
Yu LIU
- Publication Type:Journal Article
- Keywords:
Group A plus group C meningococcal glycoconjugate vaccine;
Immune dosage;
Im
- From:
Chinese Journal of Microbiology and Immunology
2008;28(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunogenicity of group A plus group C meningococeal glycoconjugate vaccine,namely dosage,immune memory and compatibility. Methods The mice were injected with group A plus group C meningococcal glycoconjugate vaccine with different dosages. Blood samples were taken on the 14th day after the last injection for testing the antibodies against polysaccharide A and C. After the optimal immunization dosage had been decided,the mice were inoculated separately with the monovalent group A and the monovalent group C and the bivalent group A plus group C glycoconjugate vaccine with one,two or three injections for observation of the effectiveness of different injections and the compatibilities. Results The dosage of 1.25 μg of each polysaccharide of group A and group C in bivalent glycoconjugate vaccine appears to be immunologically optimal to vaccinate the mice. Immunological memory could be induced in mice inoculated with the glycoconjugate vaccine,and the antigenic immunogenicity of the group A component and group C component in the formulation of group A plus group C meningococcal glycoconjugate vaccine was not affected. Conclusion Group A plus group C meningococcal glycoconjugate vaccine have good immunogenicity,immune memory and compatibility.
