The effects of repetitive transcranial magnetic stimulation of the supplementary motor area on the excitability of motor cortex in patients with Parkinson's disease
- VernacularTitle:重复经颅磁刺激辅助运动区对帕金森病患者运动皮质兴奋性的影响
- Author:
Peng ZHAO
;
Yan CHENG
;
Linyang CUI
;
Huaying TAO
;
Shijing WU
- Publication Type:Journal Article
- Keywords:
Repetitive transcranial magnetic stimulation;
Parkinson's disease;
Supplementary motor area;
Motor evoked potentials;
Somatosensory evoked potentials
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(3):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of repetitive transcranial magnetic stimulation(rTMS) of the supplementary motor area(SMA)on the cortical excitability in patients with Parkinson's disease(PD).Methods Sixteen patients with PD were included in this study.The motor evoked potentials(MEP)and the N30 component of somatosensory evoked potentials(SEP) were assessed for each patient before and after 1200 pulses of rTMS of the SMA at 5 Hz and an intensity of 100% of relaxed motor threshold (RMT) for the abductor pollicis brevis.Results Ten minutes after the rTMS intervention,the peak-to-peak amplitude of the SEP component P20-N30 increased significantly(P<0.05),with the P/F index decreased simultaneously(P<0.05).The MEP amplitude increased significantly,and reached the highest value at 10min after the rTMS intervention. Conclusion 5 Hz rTMS of the SMA can improve the excitability of the SMA itself temporarily.Meanwhile,it can induce a short-lasting facilitation of the excitability of M1 connected with SMA.
