Application of reticulocyte hemoglobin content in diagnosis of iron deficiency in premenopausal women
- VernacularTitle:网织红细胞血红蛋白含量在诊断妇女铁缺乏的临床应用
- Author:
Yu CHEN
;
Wei WU
;
Feng ZHANG
;
Jia XU
;
Dan LUO
- Publication Type:Journal Article
- Keywords:
Iron;
Deficiency diseases;
Anemia,iron-deficiency;
Erythrocyte indices
- From:
Chinese Journal of Laboratory Medicine
2008;31(2):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the application value of reticulocyte hemoglobin content (CHr)for diagnosing iron deficiency in premenopausal women.Methods The levels of CHr,hemoglobin (Hb), mean cellular volume(MCV),red cell distribution width (RDW) were measured on the ADVIA 120 (Bayer Diagnostics) automated hematology analyzer.Transferrin saturation (TS) and ferritin (SF) were measured on chemistry analyzer.Results CHr in iron deficiency without anemia group were significantly lower than that in the healthy control group (P＜0.01)and significantly higher than that in iron deficiency anemia group(P＜0.01).CHr in anemia of chronic disease group were significantly higher than that in iron deficiency anemia group(P＜0.01).Receiver operator characteristic curve (ROC) analysis in diagnosis of iron dificiency without anemia demonstrated that the area under the curve for CHr,SF,RDW,MCV,Hb were 0.872,0.798,0.721,0.713,0.677,respectively (P＜0.01).So CHr has a better overall sensitivity than SF,Hb,MCV and RDW in the diagnosis of iron deficiency without anemia.ROC also showed that the area under the curve for Hb,RDW,CHr,SF and MCV was 1.000,0.969,0.958,0.953 and 0.926,respectively (P＜0.01) in iron deficiency anemia.Conclusion CHr is the early and sensitive predictor of iron deficiency in premenopausal women,especially for the diagnosis of iron deficiency without anemia.
