Elevated serum level of VEGF in advanced non-small cell lung cancer and its clinical significance
- VernacularTitle:晚期非小细胞肺癌外周血血管内皮生长因子检测及其临床意义
- Author:
Qinxiang GUO
;
Xia SONG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Vascular endothelial growth factors;
Drug therapy,combination
- From:
Cancer Research and Clinic
2007;19(z1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the level of serum vascular endothelial growth factor(sVEGF)in advanced non-small cell lung cancer(NSCLC) and its clinical significance.Methods Serum level of VEGF was detected by ELISA method in 96 patients with advanced NSCLC.sVEGF level was analyzed after giving 2-4 cycles of cisplatin-based chemotherapy.At the same time,serum level of VEGF in 50 healthy controls was detected.Results The level of sVEGF was significantly higher in patient with lung cancer than in control group (P＜0.01).No statistical significant defference was observed between sVEGF level of stage Ⅲ and Ⅳ NSCLC patients,the patients with squamocellular lung cancer and adenocarcinoma(P＞0.05);Descended sVEGF level was found in the patients with response to chemotherapy(P＜0.05).Conclusion sVEGF can be used to evaluate chemotherapy response and diagnoses in the patients with advanced NSCLC.
