The effects of acupuncture on astrocyte proliferation after cerebral ischemia-reperfusion injury in rats
- VernacularTitle:针刺对脑缺血再灌注损伤后星形胶质细胞增生的影响
- Author:
Tieshan SONG
;
Mingfeng ZHOU
- Publication Type:Journal Article
- Keywords:
Acupuncture;
Middle cerebral artery occlusion;
Astrocyte;
CyclinD1;
Glial fibrillary acidic protein
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(4):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of acupuncture on astrocyte proliferation in hippocampus of rats after cerebral ischemia-reperfusion. Methods Ischemia-reperfusion injury was induced by temporary middle cerebral artery occlusion(MCAO)in 36 Sprague-Dawley rats,who were divided randomly into a control group,a model group and an acupuncture group.The expression level of Cyclin D 1 and glial fibrillary acidic protein(GFAP) was analyzed by immunoreactivity and Western blot. Results It was shown that the expression of Cyclin D1 and GFAP increased significantly(P＜0.01)at 2 and 7 days after cerebral ischemia-reperfusion,respectively.It was also shown that application of acupuncture could inhibit Cyclin D1 and GFAP(P＜0.01). Conclusion Acupuncture may inhibit glial proliferation by regulating cell cycle factor.
