Expression and clinical significance of hypoxia-inducible factor-1α，vescular endothelial growth factor and survivin in colorectal cancer
- VernacularTitle:人结直肠癌中缺氧诱导因子-1α、血管内皮生长因子、生存素表达及意义
- Author:
Ming LI
;
Shunying LIU
;
Donglei ZHANG
;
Baohua ZHU
;
Qianwei ZOU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Hypoxia inducible factor-1α;
Vascular endothelial growth factor;
Survivin
- From:
Chinese Journal of Digestion
2008;28(4):254-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expressions of hypoxia-inducible factor-1α(HIF-1α),vescular endothelial growth factor(VEGF)and survivin in developing colorectal cancer,and the association among them.Methods The protein expressions of HIF-1α,VEGF and survivin were detected in specimens obtained from 69 patients with colorectal cancer and 20 normal controls by immunohistochemistry.The correlations of HIF-1α,VEGF and survivin with clinicopathologic features were analyzed.Results The expression of HIF-1α,VEGF and survivin proteins in patients with colorectal cancer were 56.52%,66.67% and 46.38%,respectively,and little expressed in normal controls(P＜0.01).The expressions of HIF-1α,VEGF and survivin were closely related to the differential grade of adenocarcinoma,he in volvment of penetration,lymph node metastasis and Dukes stage(P＜0.05).In addition,HIF-1α protein expression had positive correlations with both VEGF and survivin(P＜0.05),and the expression ofVEGF also had positive correlation with survivin(P＜0.05).Conclusions HIF-1α may involve in thepathogenesis of colorectal cancer through up regulating the expressions of VEGF and survivin,which mayhave synergetic effects in the pathogenesis of colorectal cancer.
