Prevention and treatment of early hypertrophic scars with botulinum toxin type A
- VernacularTitle:A型肉毒毒素预防与治疗早期增生性瘢痕的临床初探
- Author:
Bo YU
;
Minliang CHEN
;
Wenge LIU
;
Yongcheng XU
;
Tongzhu SUN
- Publication Type:Journal Article
- Keywords:
Botulinum toxin type A;
Hypertrophic acars;
Fibroblast
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2008;14(2):98-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of botulinum toxin type A(BTXA)in the treatment of early hypertrophic scars(HTS).Methods BTXA was injected into and around the eady HTS,and then the modal and histological changes of the scars as well as the clinical reaction were observed in the patient.BTXA was also injected into muscle around the incision and effect on the cicatrization observed.Results Injection of BTXA could obviously alleviate ache and pruritus of eady HTS and could impel the atrophy and inteneration of eady HTS.Changes were found in paraffin-embedded tissue section by the hemetoxylin and eosin(HE)staining.Injection of BTXA into muscle around the cut could can reduce occurrence of HTS.Conclusion BTXA can help prevent the early HTS to a certain extent.The mechanism underlying this effect may be related to the reducing the tension around scars and proliferative activity,interfering with the signal transduction of small nerves,affecting the proliferation and apoptosis of fibroblasts and subsequently decreasing the collagen synthesis.
