Effect of adefovir combined with thymopeptides α1 in treatment of patients with chronic hepatitis B of positive HBeAg

VernacularTitle:阿德福韦酯联合胸腺肽α1治疗HBeAg阳性慢性乙型肝炎的疗效观察
Author: Zhixin ZHENG
Publication Type:Journal Article
Keywords: Hepatitis B,chronic; Adefovir; Thymopeptides α1
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(22):3048-3049
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of adefovir velocimeter(ADV) combined with Thymopeptides α1 in treatment of patients with chronic hepatitis B (CHB) against hepatitis B virus (HBV). Methods 67 cases of CHB of positive HBeAg were divided into coupling group and single group. 34 cases of coupling group, after being treated for 26 weeks with thymopeptides α1 and ADV,continued to be treated 52 weeks with ADV. 33 cases of single group were treated for 52 weeks with ADV alone. Alanine aminotransferase periodically (ALT), total bilirubin, HBV DNA,HBeAg,anti-HBe were detected at regular intervals. Efficacy were evaluated after finishing the treatment. Results The liver function were both improved obviously in two groups (P ＞ 0. 05). Frequencen of seroconversio of HBeAg/anti-HBe and negative conversion ratio of HBV DNA were much higher in coupling group than that in single group(P ＜ 0. 05). Conclusions The effects were better with Thymopeptides α1 and ADV than that with single ADV. Coupling Thymopeptides α1 and ADV could help to resist and remove HBV.