Estimation of glomerular filtration rate with different background region of interest for renography in severe renal insufficiency patients
- VernacularTitle:肾动态显像中不同本底的选取在重度肾功能不全患者肾小球滤过率的评估
- Author:
Xiaoying DU
;
Yangjun ZHU
;
Linfa LI
;
Qiang HE
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Background radiation;
Renography;
Glomeru]ar fihration rate;
Region of interest
- From:
Chinese Journal of Nephrology
2008;24(4):282-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the improvement of diagnostic accuracy with background region of interest(ROI)rectification for 99mTc-DTPA renography in patients with GFR≤plasma sampling method). Methods Thirty-three patients(age＞20 years,male/female=13/20)dose of 111 MBq/0.5 ml of 99mTc-DTPA was injected into an antecubital vein.The background ROI was selected below the kidney(Gates method,method a)or around the kidney(method b),then these two different GFR(GFRa,GFRb)were automatically estimated by computer.Meanwhile,3 ml blood samples were collected 2 h and 4 h after injection respectively,and radioactivity of 1 ml plasma was measured.GFR was calculated by dual plasma sampling method(GFRp)and the results were all standardized with the body surface area.The accuracies and correlations of GFRa and GFRb were compared to GFRp respectively. Results The correlation coefficients were ra=0.602 and rb=0.834.The median of difference of GFRa and GFRb was 8.33,-4.41.The median of absolute difference of GFRa and GFRb was 8.33,4.49.The accuracies within±15%,±30%and±50%of GFRa were 24.2%,30.3%and 48.5%,and those of GFRb were 33.3%,51.5%and 81.8%.Conclusion The background ROI around kidney can obviously improve the diagnostic accuracy of 99mTc-DTPA renography in patients with severe renal insufficiency.
