Expression of protein in cervical minimal deviation adenocarcinoma
- VernacularTitle:子宫颈微偏腺癌的蛋白表达
- Author:
Ling ZHANG
;
Quanhong WANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Adenocarcinoma;
Immunohistochemistry
- From:
Cancer Research and Clinic
2008;20(4):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the valuable index for the diagnosis of cervical minimal deviation adenocarcinoma(MDA).Methods Immunohistochemical EnVisionTM two-step method was used to evaluate the expression of CEA,Ki-67,p16,MUC6,MUC5AC,ER,PR,α-SMA in 9 samples of MDA.12 normal cervical gland tissues and 21 other types of cervical adenocarcinomas were as controls. Results The expression of CEA,MUC6,α-SMA protein in MDA(positive ratio orderly 66.67%,77.78%,88.89%)was higher than that of normal cervical gland(0,8.33%).The average Ki-67 labeling index in MDA(21.03±5.46)was also higher than that of the normal group(0.12±0.08).But as to the expression of ER and PR,the former was lower than the latter.All the differences had statistical significance (P<0.05).The expression of p16,MUC5AC had no statistical significance between the two groups(P＞0.1).The ratio of positive expression of MUC6 protein in MDA(77.78%)was higher than that of the other types of adenocarcinomas(14.29%),with the expression of p16(11.11%)lower than the latter(71.43%).All the differences had statistical significance(P＜0.01).The expression of CEA,Ki-67,MUC5AC,ER,PR,α-SMA had no statistical significance between the two groups(P＞0.05).Conclusion Immunohistochemical positive detection of CEA,Ki-67,MUC6,α-SMA perhaps make for the diagnosis of cervical MDA.The absence of ER,PR of gland cells also support MDA.Overexpression of p16 may play an impo~ant role on the occurrence and the development of some usual adenocarcinoma of cervix,but perhaps not in MDA.
