Clinicopathological analysis on glomerulonephritis complicating with acute interstitial nephritis
- VernacularTitle:肾小球肾炎合并急性间质性肾炎的临床病理分析
- Author:
Qianying ZHANG
;
Xiaoxia PAN
;
Wen ZHANG
;
Hong REN
;
Weiming WANG
;
Ya LI
;
Nan CHEN
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Acute interstitial nephritis;
Pathology;
Prognosis
- From:
Chinese Journal of Nephrology
2008;24(5):319-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the clinical characteristics and pathological changes of patients suffered from glomerulonephritis complicating with acute interstitial nephritis (AIN) . Methods Twenty one patients of glomerulonephritis complicating with AIN diagnosed by renal biopsy were retrospectively analyzed . Thirty-five pure AIN patients were selected as controls .Results Glomerulonephritis complicating AIN accounted for 37 .5% of all the AIN cases . Βlactam antibiotics and Chinese herbs were the major causes of AIN . 76 .2% of cases received further examinations due to the elevation of serum creatinine (Scr) during their follow-up of kidney injuries or during routine exams for all kinds of discomforts . Pathological features of AIN were also detected besides glomerular leisions . The impairments of renal interstitia were severe than those of the glomeruli . Eosinophil in the renal interstitia was an important indicator for the diagnosis of AIN .The renal function returned to normal or baseline in 64 .7% of the patients of glomerulonephritis complicating with AIN whose follow-up data were available . The median period for renal function restoration was 150 days (compared with 60 days in pure AIN) . But there were no significant differences between these two groups as for the rate of irreversible renal insufficiency during a follow-up period of 2 years . Conclusions Symptoms of AIN in patients of glomerulonephritis complicating with AIN tend to be masked by their glomerular diseases . Renal biopsy is of most importance for the diagnosis . Early diagnosis and treatment leads to satisfactory prognosis .