Influencing factors of erythropoietin hyporesponsiveness in patients on maintenance peritoneal dialysis and their prognostic value
- VernacularTitle:腹膜透析患者红细胞生成素低反应的影响因素及其预测价值
- Author:
Jun LIU
;
Jing HAO
;
Li ZHANG
;
Jinfang BAO
;
Qing YU
;
Weijie YUAN
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Erythropoietin;
Albumin;
C reactive protein;
Malnutrition;
Inflammation
- From:
Chinese Journal of Nephrology
2008;24(5):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the factors associated with hyporesponsiveness to erythropoietin (EPO) in patients on maintenance peritoneal dialysis (PD) . Methods Data of 114 PD patients in our PD center were collected . Patients were divided into three groups according to weekly EPO dose: hyperresponsive, hyporesponsive and normal responsive . Various factors were compared among three groups by linear correlation and ordinal regression analysis to predict EPO resistance . Results As compared to hyperresponsive and normal responsive groups,significantly lower serum hemoglobin [(78 .11±13 .42) vs (106 .28±23 .83), (96 .31±12 .33) g/L],albumin [(33 .98±4 .78) vs (39 .72±4 .26), (35 .76±4 .88) g/L], and significantly higher serum CRP [(26 .08±21 .66) vs (5 .46±1 .75), (11 .82±5 .63) mg/L], ferritin [(371 .08±89 .38) vs (289 .39±76 .84),(323 .07±62 .46) μg/L] were found in hyporesponsive group(all P ＜ 0 .01) . Erythropoietin resistance index (ERI) was correlated with CRP and albumin . Regression analysis showed that serum albumin,CRP and ferritin were strong predictors of EPO hyporespnsiveness . Conclusions Serum albumin,CRP and ferritin are closely related to hyporesponsiveness . Malnutrition and inflammatory state contribute to EPO hyporesponsiveness .
