The development of mechanism and prevention of Adriamycin-induced cardiotoxicity
- VernacularTitle:多柔比星心脏毒性机制及防治研究进展
- Author:
Feiheng CHEN
;
Yuansheng LIU
- Publication Type:Journal Article
- Keywords:
Doxorubiein;
Drug toxicity;
Heart
- From:
Cancer Research and Clinic
2008;20(4):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Adriamycin is an effective and broad-spectrum anthracycline antineoplastic agent.However,long-term therapy with adriamycin is associated with a high incidence of cumulative and irreversible cardiomyopathy. Mechanisms about adriamycin-induced cardiotoxieity are complicated, including oxidative stress,mitochondrionopathy,cardiac apoptosis,and so on.For the past few years,a series of measures aye used,which attenuate the cardiotoxicity and uninfluence the antitumor effects.The review focuses on the mechanism and prevention of adriamycin-induced cardiotoxicity in order to improve the long term survival rate of neoplastic patient.
