Combined procedure of surgical treatment and cell transplantation for dilated cardiomyopathy: initial results
- VernacularTitle:自体骨髓干细胞移植联合瓣膜手术治疗扩张型心肌病
- Author:
Huimin FAN
;
Rong LU
;
Liang MA
;
Yang LI
;
Zhongmin LIU
- Publication Type:Journal Article
- Keywords:
Cardiomyopathy,dilated;
Heart valve prosthesis implantation;
Cardiac surgical procedures;
Stem cell transplantation
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2008;24(2):95-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study evaluated the effects of combined procedure of surgical treatment and cell transplantation on dilated cardiomyopathy. Methods Eight patients (5 men and 3 women) with moderate to severe mitral regurgitation from end-stage dilated cardiomyopathy underwent surgery. Four patients were in functional class (FC) Ⅳ, six were in FC Ⅲ. There age ranged from 15 to 56 years. The preoperative ejection fraction (EF) ranged from 0.15 to 0.32 (mean 0.26 ± 0.08). Mitral valve replacement was performed in 5 patients and mitral valve repair in 3. Auto-bone marrow monenuclear cells were harvested, isolated, washed, and resuspended for direct injection after surgical procedure. Results All patients survived and were discharged from the hospital. After a mean follow-up period of 18 months ( 12 - 42 months). Echocardiography showed postoperative ejection fraction and wall movement velocity increased after 6 months. Radionuclide ventriculography showed myocardial perfusion improved significantly. Conclusion Combined procedure of surgical treatment and cell transplantation led to significant improvement in cardiac function in patients with dilated cardiomyopathy.
