Correlation between CD4+CD25+Foxp3+ regulatory T cells and disease progression in HIV infected long term non-progressors of China
- VernacularTitle:中国HIV感染长期不进展者CD4+CD25+Foxp3+调节性T细胞变化研究
- Author:
Zining ZHANG
;
Yongjun JIANG
;
Min ZHANG
;
Jing LIU
;
Wanying SHI
;
Xin JIN
;
Guoquan SUN
;
Yanan WANG
;
Xiaoxu HAN
;
Hong SHANG
- Publication Type:Journal Article
- Keywords:
HIV-1;
Regulatory T cell;
Long term non-progressor;
Foxp3;
Activation;
Apoptosis
- From:
Chinese Journal of Microbiology and Immunology
2008;28(5):450-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of CD4+CD8+Foxp3+ regulatory T cells with the HIV long term non-progressors(LTNP) in China. Methods Seventy-four HIV-1 infected patients (LTNP group, HIV group and AIDS group)and 16 normal controls were enrolled and the frequency of CD4+CD25+Foxp3+ regulatory T cells were detected by flow cytometry. To study the correlation between CD4+CD25+Foxp3+ regulatory T cells and disease progression, the absolute CD4+ T cells, viral load, apoptosis and activation of T cells were also examined. Results The frequency of CD4+CD25+Foxp3+ regulatory T cells in LTNP group was significantly lower than that in HIV and AIDS group (P<0.05). The frequency of CD4+CD25+Foxp3+ regulatory T cells was inversely related to CD4+ T cells and closely related to viral load and CD38, CD95 expression on CD4, CD8+ T cells (P<0.05). Conclusion The frequency of CD4+CD25+Foxp3+ regulatory T cells of HIV infected LTNP is significantly lower than typical progressors, which indicates that alternation of regulatory T cells may play a protective role in LTNP.
