Killer cell immunoglobulin-like receptor gene polymorphism in Hashimoto′s thyroiditis patients
- VernacularTitle:桥本甲状腺炎患者杀伤细胞免疫球蛋白样受体基因多态性分析
- Author:
Haiqing ZHANG
;
Jiajun ZHAO
;
Yueran ZHAO
;
Ling GAO
;
Lin LIAO
;
Qingbo GUAN
;
Yulian JIAO
- Publication Type:Journal Article
- Keywords:
Killer cell immunoglobulin-like receptor;
Genes;
Thyroiditis;
Autoimmune
- From:
Chinese Journal of Microbiology and Immunology
2008;28(5):454-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the killer cell immunoglobulin-like receptor (KIR) gene polymorphism with Hashimoto′s thyroiditis(HT). Methods One hundred HT patients and 260 randomly matched healthy controls were enrolled to detect the KIR genotype. The genomic DNA were extracted, and 15 selected KIR genes, KIR2DL1-5, KIR3DL1-3, KIR2DS1-5, KIR3DS1 and pseudogene KIR2DP1, were determined by a polymerase chain reaction using sequence-specific primers (PCR-SSP). Results The frequency of KIR2DL5 gene was significantly lower of the patient group than that of the control group (0.200 vs 0.312, RR=0.64, P<0.01). Conclusion There may be an association between pathogenesis of HT and KIR2DL5 gene.
