An open multicentre clinical trial for the treatment of intradialytic hypotension with midodrine-hydrochloride
- VernacularTitle:盐酸米多君治疗血液透析中低血压的多中心开放研究
- Author:
Shu RONG
;
Changlin MEI
;
Zhiyong GUO
;
Weijie YUAN
;
Qing YU
;
Jing CHEN
;
Hong FAN
;
Xiuling CHEN
;
Li WANG
;
Huifen SHEN
;
Jianhua YU
;
Yang SUN
;
Wenling YE
;
Xiaohong TANG
;
Ping FU
- Publication Type:Journal Article
- Keywords:
Midodrine;
Hypotension;
Renal dialysis;
Therapy
- From:
Chinese Journal of Nephrology
2008;24(4):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of midodrine hydrochloride in the treatment of intradialysis hypotension (IDH)in maintenance hemodialysis (MHD)patients.Methods One hundred and tburteen MHD patients from 8 dialysis centers with IDH were enrolled in the study.These patients took orMly midodfine for 4～6 weeks.Midodrine(2.5～10 mg)was given 15～30 minutes after the beginning of hemodialysis,and another 2.5～10 mg was used during hemodialysis if systolic blood pressure(SBP)increased less than 20 mm Hg.The total usage of each dialysis session was not more than 20 mg.The pre-,intra-,post-hemodialysis blood pressure and heart rate,the pre-and post-hemodialysis body weight,the uhrafiitrated volume of each dialysis,the pre-and post-treatment liver and renal function and electrocardiogram were measured and recorded.The symptoms of IDH were observed. Results Compared to those before treatment with midodrine hydrochloride,the minimum intradialysis SBP and heart rate at that time,the post-dialysis SBP and heart rate,and total uhrafiitrated volume changed significanlly (P＜0.01).The total effective rate was 84.2%.And the symptoms of IDH were improved significantly (P＜0.01).The side effects were observed in only 2 patients.Conclusion Midodrine iS safe and effective for the treatment of IDH.
