Effects of aerobic exercise on the level of plasma homocysteine,total nitric oxide synthase and nitric oxide in rats fed a high methionine diet
- VernacularTitle:有氧运动对高蛋氨酸饮食大鼠血浆Hcy、T-NOS和NO含量的影响
- Author:
Bo YANG
;
Fang LUO
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Hyperhomocysteinemia;
Nitric oxide;
Aerobic exercise
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(6):366-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of aerobic exercise on the plasma content of homocysteine (Hcy),total nitric oxide synthase(T-NOS) and nitric oxide (NO) in rats fed a high methionine diet. Methods A total of 24 male Wistar rats were randomly divided into a normal diet(CR)group,a high methionine diet(MR) group and a high methionine diet plus swimming group(T+MR),and treated accordingly for 8 weeks.At the end of the treatment,all the animals were tested for plasma T-NOS,NO and homocysteine levels.Results Plasma homo-cysteine doubled,whereas T-NOS and NO levels in the MR group decreased significantly as compared with the CR group,suggesting that hyperhomocysteinemia was induced by the high methionine diet.Plasma homocysteine content decreased significantly in the T+CR group,but plasma T-NOS and NO increased significantly compared with the MR group.These indicators were not significantly different for the T+MR group from those of the CR group. Conclu-sion Adequate aerobic exercise can decrease the plasma level of homocysteine in rats fed a high methionine diet,and increase the plasma level of T-NOS and NO,helping prevent the development of hyperhomocysteinemia.
