The effects of rehabilitation training on the expression of Nogo-A in the area surrounding cerebral infarc-tion
- VernacularTitle:康复训练对脑梗死大鼠梗死灶周围Nogo-A表达的影响
- Author:
Shurong DUAN
;
Linlin SUN
;
Kunpeng YANG
;
Chunyan WANG
;
Yuee SHEN
;
Desheng WANG
;
Liming ZHANG
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Rehabilitation;
Nogo-A;
Neural regeneration
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(6):370-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of rehabilitation training on the expression of Nogo-A around the area of cerebral infraction using rats. Methods A total of 60 Wistar rats were randomly divided into a reha- bilitation group and a control group after an experimental cerebral infarction had been established in them. The ani- mals in the rehabilitation group were given exercise with a rotating bar, a balance beam and a rolling cage for one hour daily, while those in the control group were caged without any abnormal exercise. Nogo-A expression in the ar- ea surrounding the infarcts was detected by imunohistochemical techniques at the 3rd, 7th, 14th, 21st and 28th day after infarction. Meanwhile, neurobehavioral evaluations were also conducted. Results The animals in the rehabilitation group scored much lower than the controls in the behavioral evaluations at the 14th, 21st and 28th day. The expression of Nogo-A in tissues around the infracted area increased by the 7th day and peaked at the 21st day in both groups, but the expression of Nogo-A was significantly stronger in the rehabilitation group at the 14th, 21st and 28th days. Conclusion Rehabilitation training decreased the expression of Nogo-A in the brain of rats after infarction. This may have important implications for the functional recovery of the central nervous system.
