The association between tumor necrosis factor receptor 2 gene polymorphism and development of coronary artery disease
- VernacularTitle:肿瘤坏死因子受体2基因多态性与汉族人群冠心病的相关性研究
- Author:
Guofeng XU
;
Qunli WANG
;
Yong WANG
;
Guanghua LUO
;
Jun ZHANG
;
Lu ZHENG
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Receptors,tumor necrosis factor,type Ⅱ;
Polymorphism,genetic
- From:
Chinese Journal of Laboratory Medicine
2008;31(6):675-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor receptor 2(TNFR2) gene and coronary artery disease(CAD).Methods A retrospective case control study was designed in this investigation.Patients with angiographically proven CAD (n=142)and coronary atherosclerosis(n=215)were compared to healthy volunteers(n=631). Genotyping was performed by ShineRoar probes analysis.Results People with GG genotype at position 196 in exon 6 of TNFR2 gene have more risks of development of CAD(OR=2.556,95% CI:1.051～6.218, χ2=4.57,P=0.033)and CA(OR=2.547,95% CI:1.162～5.579,χ2=5.81,P=0.016) than those with TT genotype.Further analysis after adjustment for sex and age demonstrated that GG genotype was not associated with CAD(OR=0.614,95% CI:0.166～2.279,χ2=0.53,P=0.466)and coronary atherosclerosis(OR=O.644,95%CI:0.200-2.069,χ2=0.55,P=0.459).Conclusion Tumor necrosis factor receptor 2 gene polymorphism at position 196 in exon 6 was not an independent risk factor of development of CAD and coronary atherosclerosis among Han Chinese.
