Expression of IL-23 in remission of steroid-dependent ulcerative colitis
10.3760/cma.j.issn.1007-5232.2010.06.009
- VernacularTitle:类固醇激素依赖型溃疡性结肠炎缓解期IL-23表达的研究
- Author:
Bingfeng QIU
;
Zhiyong WANG
;
Dingzhu SHEN
- Publication Type:Journal Article
- Keywords:
Colitis,ulcerative;
Steroid;
Interleukin-23
- From:
Chinese Journal of Digestive Endoscopy
2010;27(6):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathological significance of expression of IL-23 in colon tissues of patients with steroid-dependent uncreative colitis at remission.Methods Expression of IL-23 was measured by means of Western Blot and immunohistochemistry SABC in inflammation repairing areas from 15 patients with steroid-dependent ulcerative colitis at remission, 30 patients with common ulcerative colitis at remission (15 treated with SASP and 15 with prednisone) and 10 normal colon tissues.The results were analyzed by SPSS 16.0.Results Compared with normal control, expression of IL-23 in patients of SASP maintenance therapy and prednisone with common ulcerative colitis were slightly increased ( P > 0.05), which was significantly lower that of steroid-dependent specimens ( P < 0.01).Conclusion Over-expression of IL-23 may plas a key role in the pathogenesis of steroid-dependent ulcerative colitis.
