Clinical study of gabapentin in the treatment of refractory uremic pruritus in hemodialysis patients
10.3760/cma.j.issn.1001-7097.2010.05.003
- VernacularTitle:加巴喷丁治疗血液透析患者顽固性尿毒症皮肤瘙痒的临床研究
- Author:
Lin LI
;
Changlin MEI
;
Lijun SUN
;
Chaoyang YE
- Publication Type:Journal Article
- Keywords:
Pruritus;
Hemodialysis;
Uremia;
Gabapentin
- From:
Chinese Journal of Nephrology
2010;26(5):335-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the safety and efficacy of gabapentin in treatment of refractory uremic pruritus in maintenance hemodialysis (MHD)patients. Methods A randomized controlled trial was performed.Forty-nine MHD patients with severe pruritus were randomly divided into treatment group(gabapentin 100-300 mg at dialysis day before sleep)and the control group(loratadine 10 mg daily).The efficacy was assessed by visual analogue score,pruritus score and improved Duo's VAG Score after 12-week treatment,and the side effect was also observed to assess the safety. Results After treatment,the frequency,degree and area of pruritus in 25 patients of treatment group were significantly reduced,and VAS score(1.46±1.38vs 8.71±1.17,P＜0.01),VAG score(2.92±1.63 vs 8.29±0.68,P＜0.01)and the improved Duo's pruritus score(11.33±3.99 vs 30.75±4.87,P＜0.01)decreased significantly compared with that of prior treatment.The symptoms of 24 patients in control group were improved partly,which were not as good as those in treatment group(P＜0.01).The side effects of gabapentin were drowsiness and dizziness,but most symptoms were relieved or disappeared within 1 week and no patient interrupted therapy.No serious adverse events were observed. Conclusion Gabapentin is safe and effective for refractory uremic pruritus,but long-term efficacy and safety requires larger sample and long-term observation.
