Effect of nerve growth factor on colorectal visceral hypersensitivity in rats
- VernacularTitle:神经生长因子在大鼠结直肠内脏高敏感形成中的作用
- Author:
Yang YU
;
Jun GAO
;
Wei ZHANG
;
Zhaoshen LI
;
Duowu ZOU
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Visceral hypersensitivity;
Stress;
Visceromotor response
- From:
Chinese Journal of Digestion
2008;28(11):764-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the potential role of nerve growth factor(NGF)on visceral hypersensitivity in rats.Methods Visceral hypersensitivity was induced by intraperitoneal injection of NGF with or without water avoidance stress in N group(n=8)and NW group(n=8),respectively.The rats in controI group(n=8)were intraperitoneaIly injected with normal saline and received shame water avoidance stress.Electromyogram activity of the external oblique musculature was measured by means of the visceromotor response(VMR)during colorectal distention(CRD).Statistical analysis was made by ANOVA.Results There was,nb statistical difference among three groups in the VMR at pressure of 20,40 or 60 mmHg(1 mmHg=0.133 kPa).When the pressure at 80 mmHg,the VMR was higher in NW group(3.54)than that in control group(2.12)(P=0.016).while it was 2.62 in N group with no difference to control group.Conclusion The colorectal visceral sensitivity in rats may be promoted by NGF in presence of water avoidance stress.
