Expression of c-kit on amelanotic melanocyte in follicle from vitiligo patients

VernacularTitle:白癜风毛囊无色素性黑素细胞c-kit的表达
Author: Zhiwei SHANG ; Qilin LI ; Xiaohui LI ; Jinling FU
Publication Type:Journal Article
Keywords: Vitiligo; Hair follicle; Amelanotic melanocyte; C-kit
From: Chinese Journal of Medical Aesthetics and Cosmetology 2010;16(2):109-112
CountryChina
Language:Chinese
Abstract: Objective To analyse preliminarily the role of amelanotic melanocutes (AMMC) and SCF/c-kit signal pathway in the pathogenesis of vitiligo. Methods Three antibodies such as HMB-45, NKl/beteb and c-kit were used to stain sections from scalps from vitiligo patients and the healthy controls. Results There were no HMB-45 positive cells in outer root sheath(ORS) of follicle. NKI/beteb positive cells were small and located in groups at the middle and lower of outer root sheath with their retraction of the dendrites. They only expressed premelanosomal antigens but not melanosomal antigen such as HMB-45. There were no significant difference of AMMC in quantities between vitiligo patients and normal controls (P>0. 05). The expression of c-kit receptors on AMMC in follicle of depigment-ed scalps from vitiligo patients was lower than that in normal contols (P<0. 05). Conclusion Abnormal c-kit expression in AMMC in the follicle of depigmented scalps may play an important role in the pathogenesis of vitiligo.