Establishment and evaluation of a bacteriemia model in mice after infection with an isolated methicillin-resistant Staphylococcus aureus( MRSA )

VernacularTitle:耐甲氧西林金黄葡萄球菌小鼠菌血症感染模型的建立与评估
Author: Decheng WANG ; Xing WANG ; Wenjiang ZHOU ; Xiuhua PENG ; Qian GAO
Publication Type:Journal Article
Keywords: Methicillin-resistant staphylococcus aureus(MRSA); Bacteriemia; Mice model
From: Chinese Journal of Microbiology and Immunology 2010;30(7):603-607
CountryChina
Language:Chinese
Abstract: Objective To established a bacteriemia model of BALB/c mice after infection with a ST-239 methicillin-resistant staphylococcus aureus(MRSA) strain, which was isolated and identified from Shanghai Huashan Hospital. Methods We monitored the clinical signs and gross observations of MRSA-infected mice, and examined the histopathology among different groups. Results This isolated MRSA strain ST-239 can induced a typical bacteriemia in BALB/c mice, including the severe mortality and extensive histopathologic injury. However, higher survival rate and slight inflammatory injury were observed in vancomycin-treated mices. Conclusion The solid results obatined in this model will benefit us to study the pathogenic characteristics and patholgenesis in MRSA-induced bacteriemia, and propeled us to seek a safety cure approaches in the future.