The study on influenza A ( H1N1 ) virus hemagglutinin character from human and animal
10.3760/cma.j.issn.0254-5101.2010.07.011
- VernacularTitle:动物源性和人源性甲型流感病毒(H1N1)血凝素(HA)的特征分析
- Author:
Guoqiang WANG
;
Juxia NIU
;
Yanxuan LIU
- Publication Type:Journal Article
- Keywords:
Influenza A virus;
Hemagglutinin;
Homology;
Evolution tree;
H1N1
- From:
Chinese Journal of Microbiology and Immunology
2010;30(7):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the character of influenza A (H1N1) virus hemagglutinin from human and animal in order to discuss relation of hemagglutinin from between human and animal. Methods Influenza A( H1N1 ) virus hemagglutinin from human, swine and avian were downloaded from NCBI. The above hemagglutinin amino acid sequences were used to compare and establish protein evolution tree. Results Homology of influenza A( H1N1 ) virus hemagglutinin amino acid sequences from human in 2009 is high (99%-100%). But the coherence between influenza A( H1N1 ) virus hemagglutinin amino acid sequences from human in 2009, swine and avian is low, only 77% -90% ( homology is 90% between only ABW36355 from swine and influenza A( H1N1 ) virus hemagglutinin amino acid sequences from human in 2009. The other is 77%-83%). Protein evolution tree show that hemagglutinin amino acid sequences from human,swine and avian is respectively on different branch on evolution tree. The homology between influenza A(H1N1) virus hemagglutinin amino acid sequences from human in 2009(exclude ADA71154) and before 2009 is low, only 79%-80%. And hemagglutinin amino acid sequences in 2009 and before 2009 are respectively on 3 different branch of evolution tree. Conclusion Prevalent influenza A ( H1N1 ) virus in 2009 is a new virus and the study show that prevalent influenza A( H1N1 ) virus in 2009 do not directly come from swine and avian, and don't directly come from human influenza A(H1N1) virus before 2009.
