Research on the association of DC-SIGN gene promoter polymorphisms with tuberculosis
10.3760/cma.j.issn.0254-5101.2010.07.017
- VernacularTitle:DC-SIGN基因多态性与肺结核的相关性研究
- Author:
Ruijuan ZHENG
;
Lianhua QIN
;
Weibing WANG
;
Ruiliang JIN
;
Yonghong FENG
;
Zhenling CUI
;
Hua YANG
;
Zhonghua LIU
;
Jie WANG
;
Junmei LU
;
Zhongyi HU
- Publication Type:Journal Article
- Keywords:
DC-SIGN gene;
Tuberculosis;
Polymorphism;
Disease susceptibility
- From:
Chinese Journal of Microbiology and Immunology
2010;30(7):655-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of two variants( -871A/G and -336A/G) polymorphisms of the DC-SIGN gene with the susceptibility to pulmonary tuberculosis in Chinese population.Methods Two hundred and thirty-seven tuberculosis cases and 244 controls were genotyped by pyrosequencing in this case-control study. The analysis of the relationship of the -871A/G and -336A/G polymorphisms with their susceptibility of pulmonary tuberculosis(PTB) and the relationship of the two variants with their clinical correlation of tuberculosis was performed by chi-square test. Results The genotypic frequencies of A/G + G/G and A/A of - 871, 37.6%, 62.4% respectively in cases, and 43.4%, 56. 6%respectively in controls, had no significant difference in statistics. And the genotypic frequencies of A/G + G/G and A/A of -336, 12. 2% ,87.8% respectively in cases, and 14.3% ,85.7% respectively in controls, had also no statistical difference between two groups. Interestingly, a significant association is disclosed between the promoter variant - 336G allele and fever in patients ( P = 0. 037, OR = 0. 191, 95 % CI:0. 040-0. 907 ). Conclusion The single nucleotide polymorphism of -871A/G and -336A/G in DCSIGN gene promoter might not be associated with the susceptibility to tuberculosis in Chinese. Tuberculosis patients with -336G allele are significantly protected fever.
