Potential mechanism for epigastric discomfort in patients without Helicobacter pylori infection
10.3760/cma.j.issn.0254-1432.2010.08.008
- VernacularTitle:非幽门螺杆菌感染患者上腹部不适的可能机制
- Author:
Zhu JIN
;
Hejun ZHANG
;
Rongli CUI
;
Simao YE
;
Daonian LEI
;
Liya ZHOU
;
Sanren LIN
;
Yajing HAN
;
Huiru SHANG
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Gastritis;
Helicobacter pylori;
Gastric mucosa;
Pathology
- From:
Chinese Journal of Digestion
2010;30(8):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential mechanism for symptoms related to epigastric discomfort in patients without Helicobacter pylori (H.pylori) infection.Methods Patients who underwent gastric endoscopy and conformed H.pylori negative by histologic examination were enrolled.Among them,232 adult patients were collected between August 2006 and November 2006 and 31 children were collected between September 2005 and August 2009.All patients showed no apparent abnormality by endoscopic examination.The endoscopic biopsy was examined with HE or Warthin-Starry staining.Results In adult group,arteriole obstruction was found in 16 (8.8%) cases and focal haemorrhage in 82 (45.6%) cases.Both were existed in 82 (45.6%) cases.The histopathologic findings showed that arteriole obstruction in transition zone (65.2 %,P = 0.159) was common,whereas the focal haemorrhage in gastric fundus and corpus (65.6%,P=0.001) was in predominance.The symptom of heartburn was less in patients with arteriole obstruction and/or focal haemorrhage in comparison with those without these changes (x2 =8.564,P=0.003).In adolescent group,arteriole obstruction and/or focal haemorrhage accounted for 96.8% (30/31).Conclusion Gastric mucosa ischemic resulted from arteriole obstruction are commonly seen in both adult and adolescent patients,which is an important reason for epigastric discomfort in H.pylori negative patients.
