Effects of carboxyl methyl chitosan on hypertrophic scars in rabbit ears
10.3760/cma.j.issn.1671-0290.2010.04.014
- VernacularTitle:6-O-羧甲基壳聚糖对兔耳增生性瘢痕的作用
- Author:
Zheng SONG
;
Zhiguo WANG
;
Lu CHEN
;
Yahang ZHANG
;
Lin QI
;
Ruyong YAO
;
Ruixia KUANG
- Publication Type:Journal Article
- Keywords:
Hypertrophic scars;
Carboxyl methyl Chitosan;
Animal model
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2010;16(4):259-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of carboxyl methyl chitosan on hypertrophic scars by establishing a hypertrophic scar model on the ventral side of rabbit ears.Methods Full-thick-ness excisional wounds,1 cm in diameter,were made in the ears of 12 adult New Zealand white rabbits,and 123 hypertrophic sears were made in all.Then the rabbits were divided into 3 groups:group A was an experimental group (carboxyl methyl chitosan,500μg/ml),group B was a control group 1 (triamcinolone),and group C was control group 2 (physiological saline).All the scars were injected with drugs on the 30th and 40th days after operation,and then the samples were collected on the 35th and 45th day and analyzed.Results Compared with group C,group A appeared to be flatter,softer,and lighter in color;the area density of fibroblast decreased using HE stain and masson stain (P<0.05),and hydroxyproline content and hypertrophic index were also lower than group C (P<0.05).There were no significant differences of those criteria between group A and group B (P>0.05).Conclusion Injection of carboxyl methyl chitosan into Iocal hypertrophic scars On rabbit ears has similar effects to triamcinolone,and both of them can prevent and cure hypertrophic scars in proliferative stage.
