Association between polymorphism of interleukin-17F A7488G and gastric cancer in Guangdong province of China
10.3760/cma.j.issn.0254-1432.2010.08.002
- VernacularTitle:白细胞介素-17F A7488G多态性与广东地区胃癌的关系
- Author:
Zhirong ZENG
;
Xiaoqin WU
;
Lixia XU
;
Jun YU
;
Ling XUE
;
Yuantao HAO
;
Yiming WANG
;
Minhu CHEN
;
Pinjin HU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Interleukin-17;
Polymorphism,genetic;
Guangdong
- From:
Chinese Journal of Digestion
2010;30(8):507-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the association of interleukin (IL)-17F A7488G (p.His161Arg) polymorphism with gastric cancer susceptibility,clinicopathological features and survival.Methods DNA from 927 unrelated patients with gastric cancer and 777 age and gendermatched healthy controls was typed for IL-17F A7488G polymorphism by polymerase chain reactionrestriction fragment length polymorphism.Logistic regression analyses and Cox proportional hazards analyses were used to evaluate the associations between polymorphisms and gastric cancer susceptibility,clinicopathological features and survival.Results There was significant difference between healthy controls and patients with gastric cancer with respect to frequencies of IL-17FA7488G genotypes (X2= 16.55,P<0.01).After adjusted for age and gender,IL-17F A7488G GA and GG genotypes were associated with an increased risk of gastric cancer compared with the AA genotype (OR=1.51;95% CI:1.22-1.87 for GA;OR=1.61,95% CI:1.03-2.51 for GG).In comparison with AA genotype carriers,the risk of gastric cancer increased in those with GA or GG genotypes (OR= 1.53,95 % CI:1.25- 1.87,P<0.01 ).Further stratification analyses indicated that the effect of IL-17F A7488G GA genotype was especially noteworthy in gastric cancer patients of noncardia,intestinal type,poorly and moderately differentiated,and lymph node metastasis.Whereas there was no significant difference in survival among subjects with different polymorphisms of IL-17F A7488G gene (P= 0.534).Conclusions Genetic polymorphism of IL-17F A7488G involves in susceptibility to gastric cancer,which also influences certain subtypes of gastric cancer according to clinicopathological features,however,it is not the independent risk factor for prognosis of gastric cancer patients.
