Comparative study on rabeprazole and hydrotalcite in treatment of patients with bile-reflux gastritis after cholecystectomy
10.3760/cma.j.issn.0254-1432.2010.08.007
- VernacularTitle:雷贝拉唑和铝碳酸镁治疗胆囊切除术后伴胆汁反流的胃炎作用比较
- Author:
Huimin CHEN
;
Xiaobo LI
;
Zhizheng GE
- Publication Type:Journal Article
- Keywords:
Gastritis;
Duodenogastric reflux;
Rabeprazole;
Hydrotalcite
- From:
Chinese Journal of Digestion
2010;30(8):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of rabeprazole and hydrotalcite in treatment of patients with bile-reflux gastritis after cholecystectomy.MethodsPatients,who underwent cholecystectomy and were confirmed with bile reflux gastritis by 24 h gastric bilirubin monitoring,were enrolled in the study.Patients were randomly assigned into control group (n=30),rabeprazole group (n= 30,20 mg daily),hydrotalcite group (n= 29,1.0 g three times daily) and rabeprazole combined with hydrotalcite group (combination group,n= 31) and treated for 8 weeks.Dyspeptic symptoms of abdominal pain,bloating,heartburn and bitter taste were observed.The endoscopic and histological examination were performed 2 weeks after treatment to evaluate the improvement of inflammation and histological activity.The 24 h bilirubin monitoring was used to assess the total per cent of bilirubin absorption (value of 0.14 units or greater) time,the number of reflux episodes and the number of reflux episodes lasting longer than 5 min.Results The dyspeptic symptoms were relieved in three groups after treatment.However,the endoscopic oedema (2.11 ±0.77 vs 1.50 ±0.67,P<0.05) and the histological activity (2.87±0.72 vs 1.97±0.78,P<0.05) as well as the number of reflux episodes> 5 min (18.26+ 1.80 vs 9.70± 1.20) were improved most significantly in combination group after treatment.There was no statistical difference in rabeprazole and hydrotalcite groups before and after treatment.Whereas the total percent time of bilirubin absorption value >0.14 decreased in three treatment groups after treatment (P<0.05).Conclusion Rabeprazole combined with hydrotalcite is effective in the treatment of patients with bile reflux gastritis after cholecystectomy.
