The effect of electroacupuncture on brain derived neurotrophic factors in hippocampal CA3 neurons and on learning and memory ability after cerebral infarction
10.3760/cma.j.issn.0254-1424.2010.08.001
- VernacularTitle:电针百会和大椎穴两穴对脑缺血大鼠学习记忆能力和缺血侧海马CA3区脑源性神经营养因子的影响
- Author:
Xiaodong DUAN
;
Qian YU
;
Bo QIN
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Learning;
Memory;
Electroacupuncture;
Neurotrophic factors;
Rats
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2010;32(8):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of electroacupuncture (EA) at the Baihui (DU 20) and Dazhui (Bill) points on brain derived neurotrophic factor (BDNF) around the area of cerebral infarction and evaluate the relation between learning and memory ability and BDNF. Methods Forty-eight male adult Wistar rats were divided randomly and equally into EA and control groups. The EA group was sub-divided into 1 week, 2 weeks and 3weeks sub-groups. EA was started 24 h after establishing a model of ischemic brain injury and continued for one, two or three weeks. The control group was reared conventionally and was not given any treatment. Morris' water maze test was used to evaluate the rats' learning and memory ability. The expression of BDNF in the CA3 region of the hippo campus was detected using immunohistochemical techniques. Results Learning and memory in the EA groups were better than in the control group, and spatial probe ability was also significantly better. Positive expression of BDNF was detected in the hippocampal CA3 region of the EA group rats, and it was significantly greater than that in the control group. Conclusion Learning and memory after cerebral infarction can be affected by EA at the Baihui and Dazhui points. The effect might be related with increased BDNF expression in the hippocampal CA3 region.
