Efficacy analysis of different doses of cyclophosphamide in diffuse proliferative lupus nephritis
10.3760/cma.j.issn.1001-7097.2010.08.001
- VernacularTitle:不同剂量环磷酰胺治疗弥漫增殖性狼疮肾炎的疗效分析
- Author:
Xinmei ZHANG
;
Hang LI
;
Yubing WEN
;
Juan WANG
;
Xuemei LI
;
Xuewang LI
;
Zengqi BI
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Cyclophosphamide;
Prognosis
- From:
Chinese Journal of Nephrology
2010;26(8):573-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy differences of different doses of cyclophosphamide(CTX)among subcategories of diffuse proliferative lupus nephritis(LN). Methods Clinical data of 133 LN patients diagnosed by renal biopsy with class IV or class IV +V who were treated with corticosteroid plus CTX were analyzed retrospectively. The baseline Scr, 24 h urine protein, CTX dosages and prognosis were compared among different dosages for each subcategory. Results The average cumulative dose of CTX within 6 months was(11.1 4.1)g. The high dose group was >12 g, the medium dose group was >6-12 g and the low dose group was ≤6 g. Compared to low dose group, high dose CTX increased the remission rate of class Ⅳ +Ⅴ(67% vs 40%, P=0.314)and chronic renal lesion(43% vs 0%, P=0.212), but such enhancement was not obvious in class Ⅳ(Ⅳ-S: 67% vs 50%, P=0.548, Ⅳ-G: 65% vs 70%, P= 0.560). Difference of overall adverse reactions was not significant between high dose group and low dose group(51% vs 37% ,P=0.224). Conclusion Corticosteroid plus high dose CTX may improve the remission rate of patients with class IV + V and chronic renal lesions.
