Fc receptor like 3 in Han nationality of China patients with ankylosing spondylitis
10.3760/cma.j.issn.0254-5101.2010.08.016
- VernacularTitle:FcRL3基因单核苷酸多态性与中国汉族强直性脊柱炎相关性研究
- Author:
Daoqian SANG
;
Jibao YANG
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
Fc receptor like 3;
Single nucleotide polymorphism;
Haplotype
- From:
Chinese Journal of Microbiology and Immunology
2010;30(8):760-764
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between a few single nucleotide polymorphisms(SNPs) in Fc receptor like 3 and ankylosing spondylitis(AS) in Hah nationality of China patients.Methods One hundred and sixty AS patients along with one hundred and seventy healthy controls were included in the study. SNPs of FcRL3-1 (rs0158440), FcRL3-2 ( rs2225828 ), FcRL3-3 ( rs7528684 ),FcRL3-4(rs11284799), FcRL3-5(rs945635), FcRL3-6(rs3761959), FcRL3-7 (rs2210913), FcRL3-8 (ra2282284) and FcRL3-9 (rs2282283) in FcRL3 gene were genotyped by MALDI-TOF technology. Haplotypes were estimated using PHASE v2.1 software. Results The frequency of FcRL3-1-1651C, FcRL3-3-169C, FcRL3-6 Intron3A and FcRL3-7 Intron3A alleles in AS patients were significantly increased and the frequency of FcRL3-2-641C, FcR-L3-4-110A and FcRL3-9 Intron15A were significantly increased compared with healthy controls. The frequency of FcRL3-1→9 CTCGCAAAA, CCCGGGGAA, CCCGCAAAC and CTCGCAAAC haplotypes were significantly increased and the frequency of FcRL3-1→9CCTGGGAA and TCCACAAGA haplotypes were significantly decreased compared with healthy controls. Conclusion These results suggest that FcRL3 may be associated with AS in Han nationality of China.
