Clinicai investigation on esomeprazoie treatment of sixty-nine asthmatic patients with gastroesophageal reflux symptoms

VernacularTitle:埃索美拉唑治疗老年胃食管反流相关性哮喘69例临床观察
Author: Dejun YAN ; Zhengyu ZHAO
Publication Type:Journal Article
Keywords: Proton pump inhibitors; Gastroesophageal reflux; Asthma
From: Chinese Journal of Digestion 2009;29(7):479-480
CountryChina
Language:Chinese
Abstract: Objective To study the efficacy of esomeprazole in treatment of asthmatic patients with gastroesophageal reflux (GER) symptoms. Methods Sixty-nine asthmatic patients with GER symptoms were received esomeprazole 40 mg daily and mosapride 5 mg three times daily for 8 weeks. After that, esomeprazole 20 mg and mosapride 5 mg daily were prescribed to the patients for sustained therapy. The effect of asthma control was evaluated according to criteria for asthma control level made by Chinese Society of Respiratory Disease Asthma Group. All patients were followed up for 2 years.Results It was revealed that complete asthma control was achieved in 39 patients, well control in 25 patients and the total effective rate was 93 %. Asthma-control medication was stopped in 42 patients,dose reduced to 1/2 in 18 patients and continuous therapy in 9 patients. During 2 years follow-up, 58 patients were benefited from the treatment with complete asthma control and seldom attack of asthma was seen in 11 patients with reduced frequency and severity. Conclusion The symptoms of asthmatic patients with GER symptoms can be improved by esomeprazole, so that their quality of life areimproved.