Endoscopic ultrasonography-guided chemotherapeutic seeds implantation for progressive gastric cancer

VernacularTitle:内镜超声下植入化疗粒子治疗进展期胃癌的临床研究
Author: Wei LIANG ; Wanyin DENG ; Yanyan FANG ; Shijie YANG ; Deqin LIN ; Lizhen WANG ; Liping HE
Publication Type:Journal Article
Keywords: Endoscopic ultrasonography; Gastric cancer; Antineoplastic chemotherapy protocols
From: Chinese Journal of Digestive Endoscopy 2010;27(10):529-531
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of endoscopic ultrasonography(EUS)guided implantation of 5-FU seeds for progressive gastric cancer.Methods A total of 23 patients with progressive gastric cancer and outflow obstruction were enrolled into the study.During the endoscopy procedure, 45-60 5-FU seeds were implanted into the tumors with guidance of EUS, with an average dose of 100 mg.Volumes of tumor were examined with 3D-EUS before and after the treatment.Results A total of 33 procedures of 5-FU implantation were performed.By measurements of 3D-EUS, the numbers of patients with complete respons, partial response, no change, progressive disease were 1, 15, 6 and 1, respectively.In terms of outflow obstruction improvement, significant effect, obvious effect and average effect were achieved in 6, 7 and 9 patients, respectively, with an overall response rate at 91.4%.Conclusion EUS-guided 5-FU seed implantation in progressive gastric cancer is safe,reliable and effective with few complications.3D-EUS may be a new method to evaluate curative effect.