Cell type of renal allograft glomerulitis and its relationship with peritubular capillary C4d deposition
10.3760/cma.j.issn.1001-7097.2010.09.003
- VernacularTitle:移植肾小球炎的细胞类型及其与管周毛细血管C4d沉积的关系
- Author:
Juan JIN
;
Huiping WANG
;
Jie ZHAO
;
Qiang HE
;
Yan BI
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Graft rejection,acute;
Glomerulus;
Inflammation;
Macrophages;
Tcells;
C4d
- From:
Chinese Journal of Nephrology
2010;26(9):662-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cell types of renal allograft glomerulitis in posttransplantation patients and its relationship with peritubular capillary (PTC) C4d deposition.Methods Fifty-one allograft kidney transplant recipients diagnosed as acute rejection from June 2006 to June 2009 in our center were enrolled in this retrospective study. Fifty-one biopsy specimens of these patients accompanied with glomerulitis were examined by immunostain for macrophages, T cells, granzyme B, Foxp3 and C4d. Glomeular macrophages, T cells, cytotoxic T cells, regulatory T cells were counted. The recipients were divided into C4d+ and C4d- groups according to the C4d deposition in peritubular capillaries. Results The total number of glomerular infiltrating cells in C4d+ group was significantly higher than that in C4d- group (17.79±7.70 vs 8.17±3.80, P＜0.01). The infiltrating cell was predominantly macrophage in CAd+ group and significantly higher as compared to C4d- group (13.73 ±7.03 vs 2.57 ±1.22, P＜0.01).However, the infiltrating cell was predominantly T cell in C4d- group and significantly higher as compared to C4d+ group (5.60±2.81 vs 4.05±2.60, P=0.023). The infiltrating T cells in both groups were predominantly cytotoxic T cells. Conclusions The total number of infiltrating cells in glomerulitis is related to peritubular capillary C4d deposition. The infiltrating cell is predominantly macrophage in C4d+ group and predominantly T cell in C4d- group. Meanwhile the infiltrating T cell in both groups is predominantly cytotoxic T cell.
