Current situation and thinking of the prognostic gene markers' in early-stage non-small-cell lung cancer

VernacularTitle:早期非小细胞肺癌预后基因标志研究现状与思考
Author: Yang WANG ; Yilong WU
Publication Type:Journal Article
Keywords: Early-stage non-small-cell lung cancer; TNM stage; Prognostic gene signature
From: Cancer Research and Clinic 2010;22(9):577-580
CountryChina
Language:Chinese
Abstract: Non-small-cell lung cancer (NSCLC) patients with the same TNM stage may suffer from large prognosis variations. Even patients with early-stage NSCLC still demonstrated lower-than-expecting survival rates after surgical resection, indicating that the current staging methods which were based on anatomy do not adequately predict outcome. Especially the insufficient growth of very early period tumors limited the prognostic prediction of anatomy characteristics, therefore studies focusing on tumor biologic characteristics were developed in order to identify prognostic gene markers. A variety of prognostic genomic models were based on microarray analysis and quantitative polymerase chain reaction (PCR) and analyzed by bioinformatics data processing. However, the prognostic gene lists reported to date overlapped poorly in the studies with similar background. To improve the cloudy situation, the research protocol should be standardized.On the other hand, instead of simple addition of several genes, sequential combination of prognostic gene markers based on signal pathway should be developed which may possess much more rationality and systematicness.