A Case of Midline Malignant Reticulosis Associated with Distant Skin Metastases.
- Author:
Young Do KIM
;
Young Chal KYE
;
Chil Hwan OH
;
Soo Nam KIM
;
Yang Seok CHAE
- Publication Type:Case Report
- Keywords:
Midline malignant reticulosis;
Skin metastasis
- MeSH:
Antibodies, Monoclonal;
B-Lymphocytes;
Humans;
Macrophages;
Middle Aged;
Nasal Septum;
Nasopharynx;
Neoplasm Metastasis*;
Nose;
Palate;
Palate, Hard;
Paranasal Sinuses;
Respiratory System;
Skin*;
T-Lymphocytes;
Ulcer
- From:Korean Journal of Dermatology
1990;28(2):250-254
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Midline malignant reticulosis is a relentlessly progressive, localized, destructive inflammatory process of upper respiratory tract including the nose, nasopharynx, palate, paranasal sinuses, and midface. Histologically, it is characterized by a dense aceumulation of pleomorphic mononuclear cells with an admixture of inflammatory cells. We report a case of midline malignant reticulosis developed in a 64-year-old man, who showed a serosanguineous nasal discharge, perforation of nasal septum, persistent ulceration of hard palate, and disseminated lesions on the abdominal skin, which was confirmed by histopathalogical examination. In addition we studied infiltrated cells with atypical nuclei by immunohistochemical staining with a pannel of monoclonal antibodies. The results revealed that the atypical cells expressed the T-cell marker, but not the macrophage and B-cell marker.
