Expression and significance of CD147 and collagen Ⅳ in gastric carcinoma
10.3760/cma.j.issn.1006-9801.2010.10.012
- VernacularTitle:CD147及Ⅳ型胶原蛋白在原发性胃癌中的表达及其临床意义
- Author:
Youquan LI
;
Jun XING
;
Zhengzheng YAN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
CD147 protein;
Collagen Ⅳ protein;
Immunohistochemistry
- From:
Cancer Research and Clinic
2010;22(10):684-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of CD147 and collagen Ⅳ protein in gastric carcinoma.Methods Immunohistochemical assay was used to detect the expression of CD147 and collagen Ⅳ protein in 119 cases of gastric carcinoma, 20 cases of normal gastric tissues, and the clinical data was analyzed.Results In 119 cases of gastric carcinoma, the positive expression of CD147 protein was 83.2 %(99/119), the positive expression of collagen Ⅳ protein was 31.9 %(38/119). The expression of CD147 and collagen Ⅳprotein had relationship with metastasis of lymph nodes,depth of invasion and clinical phases (P ＜0.05). There was negative significant correlation between the expression of CD147 and collagen Ⅳ protein in gastric carcinoma (P＜0.01). Conclusion The expressions of CD147 and collagen Ⅳ protein may be used as one of the marks to study gastric carcinoma.
