Expression of XIAP and survivin and its significance in diffuse large B-cell lymphoma

VernacularTitle:XIAP与Suvivin蛋白在弥漫性大B细胞淋巴瘤中的表达及其临床病理意义
Author: Qunying LIANG ; Aiju FENG ; Xiuqin LIU ; Sen HE ; Ya LIU
Publication Type:Journal Article
Keywords: Lymphoma; B-lymphocytes; Prognosis; Inhibitor of apoptosis proteins; XIAP; Survivin
From: Cancer Research and Clinic 2010;22(10):689-691
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of XIAP and survivin and its significance in diffuse large B-cell lymphoma. Methods The expression of XIAP and survivin were detected by immunohistochemistry in 49 patients with diffuse large B-cell lymphomas. Results The positive rate of XIAP and survivin in cases of DLBCL were 40.8%(20/49) and 44.9%(22/49) respectively, which was higher than that of benign lymph node pathological changes (P ＜0.05). The expression of XIAP in DLBCL positively correlated with the expression of surviving (r =0.382, P =0.01). Moreover, the mean survival period in DLBCL expressing XIAP was shorter than the XIAP-negative group. Conclusion The up-regulation of expression of XIAP may play an important role in the development of DLBCL, and may cooperate with the expression of survivin in apoptosis pathway. Furthermore, the expression of XIAP might be a new unfavorable prognosis factor of DLBCL.