Hyperbaric oxygen and lipid peroxidation after spinal cord injury
10.3760/cma.j.issn.0254-1424.2010.09.005
- VernacularTitle:高压氧治疗大鼠脊髓损伤的疗效及其对脂质过氧化反应的影响
- Author:
Yongming SUN
;
Qingpeng WANG
;
Fanguo LIN
;
Haibing WANG
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Spinal cord injury;
Oxygen free radicals
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2010;32(9):654-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen (HBO) therapy following spinal cord injury (SCI) and its mechanisms. Methods Thirty Sprague-Dawley rats were randomly divided into two groups after inducing SCI models using a modified version of Allen's method. The HBO group received HBO treatment 2 h after the procedure and were then treated 100 min every day for 5 consecutive days. All the rats were evaluated 1 h before the operation, and 1 h, 10 d and 20 d afterward using BBB scores and inclined plane experiments. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured. At twenty days, all the rats were sacrificed and their spinal cords were examined pathologically using HE staining. Results Average BBB scores and climbing ability in the HBO group were better than in the control group at the 10th and 20th day after the operation. Compared to the control group, SOD increased significantly and MDA decreased significantly in the HBO group at the 2nd and 5th day after the operation. There was less cystic degeneration of the spinal cord in the HBO group. Conclusions HBO demonstrated a positive effect after SCI. Oxygen free radicals might be one of the mechanisms for the better recovery.
